Germs against pain: Humanized bacterial sodium channels
نویسندگان
چکیده
منابع مشابه
Sodium channels and pain
Although it is well established that hyperexcitability andyor increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability, suggesting increased sodium channel expression, an...
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The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function. To directly assess the lipid dependence of activity for voltage-gated sodium channels, we compared the activity of three bacterial sodium channel homol...
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OBJECTIVE To provide an overview of the role of voltage-gated sodium channels in pathophysiology of acquired and inherited pain states, and of recent developments that validate these channels as therapeutic targets for treating chronic pain. BACKGROUND Neuropathic and inflammatory pain conditions are major medical needs worldwide with only partial or low efficacy treatment options currently a...
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Our knowledge of the ion channels, receptors and signalling mechanisms involved in pain pathophysiology, and which specific channels play a role in subtypes of pain such as neuropathic and inflammatory pain, has expanded considerably in recent years. It is now clear that in the neuropathic state the expression of certain channels is modified, and that these changes underlie the plasticity of re...
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ژورنال
عنوان ژورنال: Channels
سال: 2016
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2016.1205435